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Metformin associated lactic acidosis: A case report

Authors:

U.K. Jayasundara ,

Colombo South Teaching Hospital, LK
About U.K.
Registrar in Medicine
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S, Pirasath,

Colombo South Teaching Hospital, LK
About S,
Senior Registrar in Internal Medicine
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A.G.H. Sugathapala,

Colombo South Teaching Hospital, LK
About A.G.H.
Senior Consultant Physician
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F.R. Riza

Colombo South Teaching Hospital, LK
About F.R.
Intern Medical Officer
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Abstract

Metformin, together with lifestyle intervention, is considered first-line treatment for glycemic management in people with type 2 diabetes. Despite this widespread use, one of the areas of longstanding debate has been whether metformin can be used safely in those with chronic kidney disease (CKD). The concern is the possibility of an increased risk for lactic acidosis resulting from metformin accumulation in those with renal impairment. Metformin associated lactic acidosis (MALA) is a rare complication of long-term metformin therapy and the risk is increased in patients who have concomitant risk factors like cardiac, renal or liver failure. This condition is associated with high mortality and morbidity.
How to Cite: Jayasundara, U.K., Pirasath, S., Sugathapala, A.G.H. and Riza, F.R., 2020. Metformin associated lactic acidosis: A case report. Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 10(1), pp.34–37. DOI: http://doi.org/10.4038/sjdem.v10i1.7390
Published on 01 Jun 2020.
Peer Reviewed

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