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Reading: Gonadotropin dependent precocious puberty in a boy with Prader Willi Syndrome

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Gonadotropin dependent precocious puberty in a boy with Prader Willi Syndrome

Authors:

D. S. Gamage ,

Lady Ridgeway Hospital Colombo, LK
About D. S.
Senior Registrar in Pediatric Endocrinology
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B. C. Lakmini,

Lady Ridgeway Hospital Colombo, LK
About B. C.
Senior Registrar in Pediatric Endocrinology
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B. P. Gunasekara,

Lady Ridgeway Hospital Colombo, LK
About B. P.
Senior Registrar in Pediatric Endocrinology
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D. De Silva,

Lady Ridgeway Hospital Colombo, LK
About D.
Senior Registrar in Pediatric Endocrinology
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N. Atapattu

Lady Ridgeway Hospital Colombo, LK
About N.
Consultant Pediatric Endocrinologist
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Abstract

Prader Willi Syndrome is a severe obesity syndrome due to the absence of paternal expression of imprinted genes localized at 15q11.2-q13. It is characterized by short stature, hypotonia, and feeding difficulties in infancy. Hypothalamic pituitary dysfunction is seen in this syndrome resulting in growth hormone deficiency and hypogonadism. Thus, the usual manifestation of this syndrome will be delayed puberty and infertility. Gonadotropin-dependent precocious puberty is a very rare manifestation, where some cases are associated with growth hormone therapy. We report eight years and eight-month-old boy presented to us with Prader Willi Syndrome and type 2 diabetes, who developed central precocious puberty.

How to Cite: Gamage, D.S., Lakmini, B.C., Gunasekara, B.P., De Silva, D. and Atapattu, N., 2021. Gonadotropin dependent precocious puberty in a boy with Prader Willi Syndrome. Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 11(2), pp.47–49. DOI: http://doi.org/10.4038/sjdem.v11i2.7454
Published on 23 Nov 2021.
Peer Reviewed

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