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Case Reports

Challenges in the diagnosis and management of Cushing’s syndrome due to ectopic ACTH from bronchial carcinoid

Authors:

M. S. A. Cooray ,

National hospital of Sri Lanka, LK
About M. S. A.
Department of endocrinology
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N. P. Somasundaram,

National hospital of Sri Lanka, LK
About N. P.
Department of endocrinology
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Janakie Fernando,

National hospital of Sri Lanka, LK
About Janakie
Department of pathology
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A. H. N. Fernando,

National hospital of Sri Lanka, LK
About A. H. N.
Department of medicine
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R. M. De Silva,

National hospital of Sri Lanka, LK
About R. M.
Department of pathology
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D. Rasnayake

National hospital of Sri Lanka, LK
About D.
Department of cardiothoracic surgery
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Abstract

Despite the advances in biochemical methods and imaging techniques, Cushing’s syndrome (CS) related to ectopic adrenocorticotrophic hormone (ACTH) secretion continues to pose diagnostic and therapeutic challenges to the clinician. The work up involves establishment of endogenous Cushing’syndrone, diagnosis of ACTH dependency, localization of the source of ACTH secretion and rapid biochemical control of hypercortisolaemia. The diagnostic pathway is made difficult by recurrent sepsis, relative hypoadrenalism, drug side effects as well as unmasked incidental lesions.

 

We report a patient presenting with Cushing’s syndrome associated with ectopic ACTH secretion from abronchial carcinoid whose management presented multiple diagnostic and therapeutic challenges.
How to Cite: Cooray, M.S.A. et al., (2015). Challenges in the diagnosis and management of Cushing’s syndrome due to ectopic ACTH from bronchial carcinoid. Sri Lanka Journal of Diabetes Endocrinology and Metabolism. 5(2), pp.95–99. DOI: http://doi.org/10.4038/sjdem.v5i2.7289
Published on 28 Aug 2015.
Peer Reviewed

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