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Reading: Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus

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Original Papers

Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus

Authors:

A. K. M. Saber Ahmed,

Sylhet M A G Osmani Medical College, Sylhet, BD
About A. K. M.
Department of Biochemistry
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A. B. M. Kamrul-Hasan ,

Mymensingh Medical College Hospital, Mymensingh, BD
About A. B. M.
Department of Endocrinology

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Mohammed Ruhul-Kabir,

Sylhet M A G Osmani Medical College, Sylhet, BD
About Mohammed
Department of Medicine
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Habibur Rahman,

Sylhet M A G Osmani Medical College, Sylhet, BD
About Habibur
Department of Endocrinology
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Mohammad Shofiullah,

Sylhet M A G Osmani Medical College, Sylhet, BD
About Mohammad
Department of Medicine
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A. F. M. Nazmul-Islam

Sylhet M A G Osmani Medical College, Sylhet, BD
About A. F. M.
Department of Medicine
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Abstract

C-peptide is produced in equimolar amounts to insulin and is the best measure of endogenous insulin secretion. This cross-sectional study was conducted in a tertiary hospital of Bangladesh from January 2016 to December 2017 to assess fasting serum c-peptide as a marker of the endogenous insulin secretory capacity in newly diagnosed subjects with type 2 diabetes mellitus (T2DM). 60 newly diagnosed T2DM subjects were investigated along with 30 age-sex matched healthy controls. Fasting c-peptide was significantly higher in T2DM subjects than controls (8.97±5.96 vs. 1.69±0.66 ng/ml). None of the T2DM subjects had subnormal c-peptide, 19 (32%) had normal c-peptide, and 41 (68%) of them had elevated c-peptide levels. Higher fasting plasma glucose (FPG), plasma glucose 2-hours after 75gm oral glucose tolerance test (PG 2H-OGTT) and HbA1c levels were observed in T2DM subjects with elevated c-peptide in comparison to T2DM subjects having normal c-peptide. In T2DM subjects, c-peptide showed significant positive correlations with body mass index (BMI), FPG, PG 2H-OGTT, and HbA1c. This study found higher levels of fasting c-peptide in newly diagnosed T2DM in comparison to nondiabetic controls. None of the T2DM subjects had a subnormal c-peptide level.
How to Cite: Saber Ahmed, A.K.M., Kamrul-Hasan, A.B.M., Ruhul-Kabir, M., Rahman, H., Shofiullah, M. and Nazmul-Islam, A.F.M., 2019. Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus. Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 9(2), pp.25–30. DOI: http://doi.org/10.4038/sjdem.v9i2.7395
Published on 12 Dec 2019.
Peer Reviewed

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